期刊
TRENDS IN GENETICS
卷 32, 期 4, 页码 211-224出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2016.02.001
关键词
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资金
- NIH [R00CA175290]
- University of Texas Rising STARs award
- Texas CPRIT grant [RR140071]
- UT Southwestern Endowed Scholar Program
- Cancer Prevention and Research Institute of Texas [CPRIT R1103]
- Welch Foundation [1-1800]
- National Institutes of Health (NIH) [GM114160]
- University of Texas Specialized Program of Research Excellent in Lung Cancer [NIH CA70907]
- American Cancer Society (Research Scholar Grant) [RSG-15-062-01-TBE]
- American Cancer Society (Institutional Research Grant) [IRG-02-196-07]
- US National Cancer Institute (NCI
- MD Anderson TCGA Genome Data Analysis Center) [CA143883]
- Cancer Prevention Research Institute of Texas (CPRIT) [RP130397]
- Mary K. Chapman Foundation
- Michael & Susan Dell Foundation
- MD Anderson Cancer Center Support Grant [P30 CA016672]
Complex diseases, such as cancer, are often associated with aberrant gene expression at both the transcriptional and post-transcriptional level. Over the past several years, competing endogenous RNAs (ceRNAs) have emerged as an important class of post-transcriptional regulators that alter gene expression through a miRNA-mediated mechanism. Recent studies in both solid tumors and hematopoietic malignancies showed that ceRNAs have significant roles in cancer pathogenesis by altering the expression of key tumorigenic or tumor-suppressive genes. Characterizing the identity, function, and mechanism of the ceRNAs will not only further our fundamental understanding of RNA-mediated cancer pathogenesis, but may also shed light on the development of new RNA based therapeutic strategies for treating cancer.
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