期刊
TRENDS IN GENETICS
卷 32, 期 11, 页码 697-706出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2016.09.004
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资金
- Association pour la Recherche sur le Cancer (Equipe Labellisee)
- Agence Nationale pour la Recherche [ANR-15-CE12-0004-01]
- IdEx Paris Sorbonne
- Inserm
- Agence Nationale de la Recherche (ANR) [ANR-15-CE12-0004] Funding Source: Agence Nationale de la Recherche (ANR)
DNA replication is a highly regulated process that ensures the correct duplication of the genome at each cell cycle. A precise cell type-specific temporal program controls the duplication of complex vertebrate genomes in an orderly manner. This program is based on the regulation of both replication origin firing and replication fork progression. G-quadruplexes (G4s), DNA secondary structures displaying noncanonical Watson-Crick base pairing, have recently emerged as key controllers of genome duplication. Here we discuss the various means by which G4s affect this fundamental cellular process.
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