期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 27, 期 12, 页码 881-892出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2016.08.006
关键词
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资金
- NIDDK-National Institutes of Health [R01 DK098240-01]
- American Diabetes Association Basic Science Research Award [7-13-BS-131, DK102772]
- Department of Biotechnology, India
Skeletal muscle constitutes,similar to 40% of body mass and has the capacity to play a major role as thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also contributes to nonshivering thermogenesis via futile sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) activity. Sarcolipin (SLN), a regulator of SERCA activity in muscle, plays an important role in regulating muscle thermogenesis and metabolism. Uncoupling of SERCA by SLN increases ATP hydrolysis and heat production, and contributes to temperature homeostasis. SLN also affects whole-body metabolism and weight gain in mice, and is upregulated in various muscle diseases including muscular dystrophy, suggesting a role for SLN during increased metabolic demand. In this review we also highlight the physiological roles of skeletal muscle beyond contraction.
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