Scientific Significance of Clinically Insignificant FcγRIIIa-V158F Polymorphism

Kenkre and colleagues report the absence of correlation between Fc gamma RIIIa-V158F polymorphism and rituximab response in follicular lymphoma patients, a result which is in contrast with prior studies. This discrepancy recalls that many other factors (from the host and from the tumor) may influence the efficacy of rituximab in vivo. (C) 2015 AACR.