期刊
TRENDS IN CELL BIOLOGY
卷 26, 期 7, 页码 535-546出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.02.007
关键词
-
类别
资金
- Mathers foundation
- National Institute of General Medical Sciences (NIGMS) [R01GM-097194, R01GM-099844]
How proteins specifically localize to the phospholipid monolayer surface of lipid droplets (LDs) is being unraveled. We review here the major known pathways of protein targeting to LDs and suggest a classification framework based on the localization origin for the protein. Class I proteins often have a membrane embedded, hydrophobic 'hairpin' motif, and access LDs from the endoplasmic reticulum (ER) either during LD formation or after formation via ER-LD membrane bridges. Class II proteins access the LD surface from the cytosol and bind through amphipathic helices or other hydrophobic domains. Other proteins require lipid modifications or protein-protein interactions to bind to LDs. We summarize knowledge for targeting and removal of the different classes, and highlight areas needing investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据