期刊
TRENDS IN CELL BIOLOGY
卷 26, 期 11, 页码 875-888出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.08.004
关键词
-
类别
资金
- Center of Synthetic Biology and Shanghai Institute of Rheumatology in Renji Hospital [81502233]
- Science and Technology Commission of Shanghai Municipality [134119a8100]
- Young Scientific Research Project of Shanghai Municipal Health Bureau [20134Y176]
- NIH Office of the Director (OD)
- National Institute of Dental & Craniofacial Research (NIDCR)
- NIH Director's Early Independence Award [DP5 OD017887]
Recent advances in genome engineering are starting a revolution in biological research and translational applications. The clustered regularly interspaced short palindromic repeats (CRISPR)-associated RNA-guided endonuclease CRISPR associated protein 9 (Cas9) and its variants enable diverse manipulations of genome function. In this review, we describe the development of Cas9 tools for a variety of applications in cell biology research, including the study of functional genomics, the creation of transgenic animal models, and genomic imaging. Novel genome engineering methods offer a new avenue to understand the causality between the genome and phenotype, thus promising a fuller understanding of cell biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据