β-Catenin-Independent Roles of Wnt/LRP6 Signaling

Wnt/LRP6 signaling is best known for the beta-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of beta-catenin and transcription. We review here the molecular mechanisms underlying beta-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.