期刊
TRENDS IN CELL BIOLOGY
卷 26, 期 8, 页码 563-565出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.06.006
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资金
- Howard Hughes Medical Institute Funding Source: Medline
The mitochondria, unfolded protein response (UPRmt) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPRmt activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPRmt and provides a possible therapeutic target for diseases associated with mtDNA mutations.
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