期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 26, 期 3, 页码 209-218出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2015.07.002
关键词
Myocardial excitability; Arrhythmias; MicroRNAs; Transcription factors; Long non-coding RNAs; Cardiac hypertrophy; Heart failure; Diabetes
资金
- US National Institutes of Health, United States [HL034161, HL066388]
- Taiwan Ministry of Science and Technology [MOST103-2320-B-002-068-MY2]
- Taiwan National Health Research Institute (Career Development Grant) [NHRI-EX104-10418SC]
In the mammalian heart, multiple types of K+ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K+ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K+ channel diversity. Maladaptive remodeling of K+ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational, and epigenetic mechanisms contributing to regulating the expression, distribution, and remodeling of cardiac K+ channels under physiological and pathological conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据