期刊
TRENDS IN BIOTECHNOLOGY
卷 34, 期 5, 页码 420-433出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2016.02.001
关键词
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资金
- National Basic Research Program of China (863 Program) [2015AA020502]
- National Science Foundation of China [81571744, 81301257]
- Science Foundation of Fujian Province [2014Y2004]
- Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Photoacoustic imaging (PAI) has ushered in a new era of observational biotechnology and has facilitated the exploration of fundamental biological mechanisms and clinical translational applications, which has attracted tremendous attention in recent years. By converting laser into ultrasound emission, PAI combines rich optical contrast, high ultrasonic spatial resolution, and deep penetration depth in a single modality. This evolutional technique enables multiscale and multicontrast visualization from cells to organs, anatomy to function, and molecules to metabolism with high sensitivity and specificity. The state-of-the-art developments and applications of PAI are described in this review. Future prospects for clinical use are also highlighted. Collectively, PAI holds great promise to drive biomedical applications towards early-stage theranostics.
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