期刊
TRENDS IN BIOTECHNOLOGY
卷 34, 期 5, 页码 394-407出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2016.01.002
关键词
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资金
- Dutch Arthritis Foundation
- European Community's Seventh Framework Programme (FP7) [309962]
- European Research Council [647426]
- European Research Council (ERC) [647426] Funding Source: European Research Council (ERC)
- ReumaFonds [LLP-12] Funding Source: researchfish
Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GeIMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GeIMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.
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