期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 41, 期 5, 页码 460-471出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.02.003
关键词
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资金
- British Heart Foundation [FS/12/38/29640]
- National Institutes of Health Research
- Medical Research Council, UK
- Istituto Pasteur, Fondazione Cenci-Bolognetti
- British Heart Foundation
- British Heart Foundation [FS/12/38/29640] Funding Source: researchfish
- Medical Research Council [1263270] Funding Source: researchfish
The integration of biochemistry into immune cell biology has contributed immensely to our understanding of immune cell function and the associated pathologies. So far, most studies have focused on the regulation of metabolic pathways during an immune response and their contribution to its success. More recently, novel signalling functions of metabolic intermediates are being discovered that might play important roles in the regulation of immunity. Here we describe the three long-known small metabolites lactate, acetyl-CoA, and succinate in the context of immunometabolic signalling. Functions of these ubiquitous molecules are largely dependent on their intra- and extracellular concentrations as well as their subcompartmental localisation. Importantly, the signalling functions of these metabolic intermediates extend beyond self-regulatory roles and include cell-to-cell communication and sensing of microenvironmental conditions to elicit stress responses and cellular adaptation.
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