Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed

Two-pore channels (TPCs) are intracellular Ca2+-permeable ion channels that are expressed on acidic Ca2+ stores. They are co regulated by voltage and Ca2+ in plant vacuoles and by the second messenger NAADP in animal endolysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.