期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 41, 期 10, 页码 847-858出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.07.008
关键词
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资金
- Research Council of Norway
- KG Jebsen Research Foundation
- UK Biotechnology and Biological Sciences Research Council
- Medical Research Council
- South Australian Health & Medical Research Institute
The eukaryotic translation initiation factor (eIF) 4E, which binds to the 5'-cap of mRNA, undergoes phosphorylation on a single conserved serine, executed by the mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). However, the functional consequences and physiological roles of MNK signalling have remained obscure. Now, new pharmacological and genetic tools have provided unprecedented insights into the function of MNKs and eIF4E phosphorylation. The studies suggest that MNKs control the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, cytoplasmic fragile - X protein-interacting protein 1 (CYFIP1). These recent breakthroughs go a long way to resolving the longstanding enigma and controversy surrounding the function of the MNK-eIF4E axis in cancer cell biology and neurobiology.
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