期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 41, 期 4, 页码 356-370出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.01.007
关键词
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资金
- National Heart, Lung, and Blood Institute [HL121718]
- American Heart Association [14GRNT20310017]
- American Society of Hematology
The UbiA superfamily of intramembrane prenyltransferases catalyzes a key biosynthetic step in the production of ubiquinones, menaquinones, plastoquinones, hemes, chlorophylls, vitamin E, and structural lipids. These lipophilic compounds serve as electron and proton carriers for cellular respiration and photosynthesis, as antioxidants to reduce cell damage, and as structural components of microbial cell walls and membranes. This article reviews the biological functions and enzymatic activities of representative members of the superfamily, focusing on the remarkable recent research progress revealing that the UbiA superfamily is centrally implicated in several important physiological processes and human diseases. Because prenyltransferases in this super family have distinctive substrate preferences, two recent crystal structures are compared to illuminate the general mechanism for substrate recognition.
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