Experience with belatacept rescue therapy in kidney transplant recipients

In kidney transplant recipients with chronic graft dysfunction, long-term immunosuppression with calcineurin inhibitors (CNIs) or mTOR inhibitors (mTORi) can be challenging due to adverse effects, such as nephrotoxicity and proteinuria. Seventy-nine kidney transplant recipients treated with CNI-based or mTORi-based maintenance immunosuppression who had CNI-induced nephrotoxicity or severe adverse events were switched to belatacept. Mean time from transplantation to belatacept conversion was 69.0 months. Mean estimated glomerular filtration rate (eGFR) +/- standard deviation at baseline was 26.1 +/- 15.0 ml/min/1.73 m(2), increasing to 34.0 +/- 15.2 ml/min/1.73 m(2) at 12 months postconversion (P < 0.0005). Renal function improvements were also seen in patients with low eGFR (< 25 ml/min/1.73 m(2)) or high proteinuria (> 500 mg/l) at conversion. The Kaplan-Meier estimates for patient and graft survival at 12 months were 95.0% and 85.6%, respectively. The discontinuation rate due to adverse events was 7.9%. One case of post-transplant lymphoproliferative disorder occurred at 17 months postconversion. For comparison, a historical control group of 41 patients converted to mTORi-based immunosuppression because of biopsy-confirmed CNI-induced toxicity was examined; eGFR increased from 27.6 +/- 7.2 ml/min/1.73 m(2) at baseline to 31.1 +/- 11.9 ml/min/1.73 m(2) at 12 months (P = 0.018). Belatacept-based immunosuppression may be an alternative regimen for kidney transplant recipients with CNI-or mTORi-induced toxicity.