期刊
TRANSFUSION AND APHERESIS SCIENCE
卷 55, 期 1, 页码 146-152出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2016.06.001
关键词
Extracorporeal photochemotherapy; Melanoma antigen recognized by T cells-1 (MART-1); Antigen-presenting cell (APC); CD8 T cell proliferation
类别
Extracorporeal photochemotherapy (ECP), or photopheresis, is distinguished by the specificity of the clinically potent immunologic reactions it initiates or regulates. The selectivity of ECP-induced immunoprotection for the malignant clone in cutaneous T cell lymphoma (CTCL), and for the pathogenic clones in allograft rejection and graft-versus-host disease (GVHD), has suggested a central mechanistic role for dendritic antigen presenting cells (DC). Discovery of ECP's induction of monocyte-derived DC, via monocyte signaling by ECP-plate activated platelets, and the absolute dependency of experimental ECP on such induced DC, supports that premise. Herein, we show that ECP-induced DC are capable of stimulating CD8 T cell responses to tumor antigens with which they are loaded. They internalize an antigen-specific melanoma-associated protein then present it onto a class I major his-to compatibility, which then stimulates expansion of anti-tumor CD8 T cell populations. We conclude that ECP-induced DC prominently contribute to its initiation of anti-tumor immunity and raise the possibility that the therapy may be applicable to the immunotherapeudc management of a broader spectrum of cancers. (C) 2016 Published by Elsevier Ltd.
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