期刊
TOXICON
卷 121, 期 -, 页码 41-50出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2016.08.012
关键词
Palytoxin; Hydroxypalytoxin; Deoxypalytoxin; LC-HRMS; ELISA
资金
- International Research Hub Project for Climate Change and Coral Reef/Island Dynamics, at the University of the Ryukyus
- Programme STAR Linea 1 [VALTOX] - UniNA [Napoli_call2013_08]
- Compagnia di San Paolo
Palytoxin (PLTX) is a lethal natural toxin often found in Palythoa zoantharians that, together with its congeners, may induce adverse effects in humans after inhalation of toxic aerosols both in open-air and domestic environments, namely in the vicinity of public and private aquaria. In this study, we describe a poisoning of an aquarium hobbyist who was hospitalized after handling a PLTXs-containing zoantharian hexacoral. Furthermore, we provide evidence for water detoxification. The zoantharian was morphologically and genetically identified as Palythoa cf. toxica (Cnidaria: Anthozoa). Palytoxin itself and two new PLTX congeners, a hydroxyPLTX and a deoxyPLTX, were detected and structurally identified by liquid chromatography high resolution multiple stage mass spectrometry (LC-HRMSn, n = 1, 2). Total and individual toxins were quantified by LC-HRMS and sandwich ELISA both in the zoantharian (93.4 and 96.80 mu g/g, respectively) and in the transport water (48.3 and 42.56 mu g/mL, respectively), with an excellent mean bias of 1.3% between the techniques. Activated carbon adsorbed 99.7% of PLTXs contained in the seawater and this represents a good strategy for preventing aquarium hobbyist poisonings. (C) 2016 Elsevier Ltd. All rights reserved.
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