期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 299, 期 -, 页码 30-40出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2016.01.022
关键词
Nanomaterials; Pathophysiologic effects; Nano-bio interaction; Safety; Biomedical effects
资金
- National Basic Research Program of China [2012CB934000]
- National Natural Science Foundation of China [11205166, 21320102003]
- National Science Fund for Distinguished Young Scholars [11425520]
- International Science & Technology Cooperation Program of China [2014DFG52500]
- Ministry of Science Technology of China [2011YQ030134]
- Beijing NSF [2152037]
Nanomaterials (NMs) have been widespread used in biomedical fields, daily consuming, and even food industry. It is crucial to understand the safety and biomedical efficacy of NMs. In this review, we summarized the recent progress about the physiological and pathological effects of NMs from several levels: protein-nano interface, NM-subcellular structures, and cell-cell interaction. We focused on the detailed information of nano-bio interaction, especially about protein adsorption, intracellular trafficking, biological barriers, and signaling pathways as well as the associated mechanism mediated by nanomaterials. We also introduced related analytical methods that are meaningful and helpful for biomedical effect studies in the future. We believe that knowledge about pathophysiologic effects of NMs is not only significant for rational design of medical NMs but also helps predict their safety and further improve their applications in the future. (C) 2016 Elsevier Inc All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据