期刊
TOXICOLOGIC PATHOLOGY
卷 45, 期 1, 页码 94-106出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623316672743
关键词
animal models; preclinical research & development; geographic origin; rat; cynomolgus monkey; genetic variability; environment
It has been long established that not only the species but also the strain and supplier of rodents used in preclinical safety studies can have a significant impact on the outcome of studies due to variability in their genetic background and thus spontaneous pathologic findings. In addition, local husbandry, housing, and other environmental conditions may have effects on the development and expression of comorbidities, particularly in longer-term or chronic studies. More recently, similar effects related to the source, including genetic and environmental variability, have been recognized in cynomolgus macaques (Macaca fascicularis). The increased use of cynomolgus macaques from various sources of captive-bred animals (including nonnative, U. S./European Union-based breeding facilities or colonies) can affect study design and study results and outcome. It is important to acknowledge and understand the impact of this variability on the results and interpretation of research studies. This review includes recent examples where variability of preclinical animal models (rats and monkeys) affected the postmortem observations highlighting its relevance to study design or interpretation in safety studies.
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