期刊
CLINICAL AUTONOMIC RESEARCH
卷 25, 期 1, 页码 77-80出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10286-015-0273-2
关键词
Multiple system atrophy; Alpha-synuclein; Ferroportin; Beclin-1
资金
- CurePSP foundation
- Mayo Funds
We used double immunocytochemistry for alpha-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.
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