期刊
THYROID
卷 26, 期 2, 页码 306-318出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/thy.2015.0319
关键词
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资金
- Swedish Research Council
- Swedish Cancer Foundation
- Karolinska Institutet, Stockholm, Sweden
- American Cancer Society
- National Cancer Institute [R01 CA77398, R01 CA39742, CA-34933, CA-40360, CA-097193, R37 CA070867, UM1 CA182910, R01 CA082729, UM1 CA173640, K05-CA154337]
- California Department of Public Health (CDPH) [103885]
- NCI's SEER program [HHSN261201000140C, HHSN261201000035C, HHSN261201000034C]
- Centers for Disease Control and Prevention's (CDCP) National Program of Cancer Registries [U58DP003862-01]
- World Cancer Research Fund [2009/92]
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Danish Cancer Society, Denmark
- Ligue Contre le Cancer, France
- Institut Gustave Roussy, France
- Mutuelle Generale de l'Education Nationale, France
- Institut National de la Sante et de la Recherche Medicale, France
- Deutsche Krebshilfe, Germany
- Deutsches Krebsforschungszentrum
- Federal Ministry of Education and Research, Germany
- Hellenic Health Foundation, Greece
- Italian Association for Research on Cancer
- National Research Council, Italy
- Dutch Ministry of Public Health, Welfare and Sports, the Netherlands
- Netherlands Cancer Registry, the Netherlands
- LK Research Funds, the Netherlands
- Dutch Prevention Funds, the Netherlands
- Dutch ZON (Zorg Onderzoek Nederland), the Netherlands
- World Cancer Research Fund, London, UK
- Statistics Netherlands, the Netherlands
- European Research Council, Norway
- Health Research Fund
- Regional Government of Andalucia [6236]
- Regional Government of Asturias [6236]
- Regional Government of Basque Country [6236]
- Regional Government of Murcia [6236]
- Navarra, ISCIII RETIC, Spain [RD06/0020/0091]
- Swedish Cancer Society, Sweden
- Swedish Scientific Council, Sweden
- Regional Government of Skane
- Vasterbotten, Sweden
- Cancer Research United Kingdom
- Medical Research Council, United Kingdom
- Stroke Association, United Kingdom
- British Heart Foundation, United Kingdom
- Department of Health, Food Standards Agency, United Kingdom
- Wellcome Trust
- French National Cancer Institute (L'Institut National du Cancer
- INCA) [2009-139]
- Ligue contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid
- German Cancer Research Center (DKFZ)
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Health Research Fund (FIS) of the Spanish Ministry of Health (RTICC) [DR06/0020/0091]
- regional government from Asturias
- regional government from Andalucia
- regional government from Murcia
- regional government from Navarra
- regional government from Vasco Country
- Catalan Institute of Oncology of Spain
- Cancer Research UK
- Medical Research Council, UK
- Stroke Association, UK
- British Heart Foundation
- Department of Health, UK
- Food Standards Agency, UK
- Wellcome Trust, UK
- Hellenic Health Foundation
- Compagnia San Paolo, Italy
- Dutch Ministry of Public Health, Welfare and Sports
- Dutch Ministry of Health
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane, Sweden
- Nordforsk-Centre of Excellence programme
- National Health and Medical Research Council of Australia [209057, 251533]
- National Heart, Lung, and Blood Institute [HL-26490, HL-34595]
- National Institutes of Health, Bethesda, MD
- NIH, National Institute of Environmental Health Sciences [ZO1-ES-044005]
- Office of Dietary Supplements [K05-CA154337]
Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5cm)=1.07 [1.04-1.10], BMI (per 5kg/m(2))=1.06 [1.02-1.10], waist circumference (per 5cm)=1.03 [1.01-1.05], young-adult BMI (per 5kg/m(2))=1.13 [1.02-1.25], and adulthood BMI gain (per 5kg/m(2))=1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p=0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.
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