期刊
THROMBOSIS RESEARCH
卷 139, 期 -, 页码 85-89出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2016.01.016
关键词
Aortic stenosis; Coagulation; Bleeding; von Willebrand factor; Valve replacement; Heyde syndrome
资金
- Polish Ministry of Science [N N402 383338]
- Jagiellonian University [K/ZDS/005695]
Aortic stenosis (AS), the most prevalent acquired valvular disease in the adults that requires invasive treatment, coexists with coagulopathy, resulting in bleeding in approximately 20% of patients. In the current review, we summarize the available knowledge on the mechanisms underlying the bleeding tendency observed in AS, and discuss potential compensatory mechanisms preventing most patients with severe AS from experiencing bleeding. We offer an update on Heyde's syndrome and other types of bleeding, and study extensively their pathobiology, providing insights into the new emerging concepts on coagulation regulation in AS. The focus is given to the impact of valvular interventions on coagulation abnormalities in AS. Both surgical valve replacement and transcatheter aortic valve implantation are discussed. Finally, we discuss current treatment recommendations in AS related bleeding. (C) 2016 Elsevier Ltd. All rights reserved.
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