期刊
THROMBOSIS AND HAEMOSTASIS
卷 116, 期 4, 页码 626-637出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH16-02-0091
关键词
Atherosclerosis; leukocyte function / activation; monocytes
资金
- Biotechnology and Biological Sciences Research Council [BBS/B/01057] Funding Source: researchfish
- British Heart Foundation [PG/09/069/27905, FS/14/42/30956, RG/12/7/29693] Funding Source: researchfish
- Novo Nordisk Fonden [NNF15SA0018346] Funding Source: researchfish
Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.
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