期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 42, 期 2, 页码 154-161出版社
WILEY
DOI: 10.1111/1440-1681.12330
关键词
ankylosing spondylitis; follicular helperT cells; follicular regulatoryT cell; immunoglobulinA; interleukin-21; suppressive function
资金
- National Natural Science Foundation of China [30972610, 81273240]
- Jilin Province Science and Technology Agency [20110716]
- Health Department Research Projects in Jilin Province [2009Z054]
- Norman Bethune Program of Jilin University [2012206]
Follicular helperT (TFH) cells and Bcells are linked to the pathogenesis of ankylosing spondylitis (AS). Follicular regulatoryT (TFR) cells suppress TFH cell and germinal center Bcell numbers invivo. The role of TFR cells in AS is unknown. The frequency of peripheral blood inducible FOXP3+CXCR5+CD4+TFR cells and CXCR5+CD4+TFH cells were taken from 20 onset AS patients and 10 healthy controls, and were examined by flow cytometry, their disease activity were measured by the Bath Ankylosing Spondylitis Disease Activity Index. The concentrations of serum interleukin (IL)-21, immunoglobulinG, immunoglobulinA, immunoglobulinM and C-reactive protein were examined, and the values of erythrocyte sedimentation rate were measured. The frequency of peripheral blood FOXP3+CXCR5+CD4+TFR cells, CXCR5+CD4+TFH cells, the ratio of FOXP3+CXCR5+CD4+TFR/CXCR5+CD4+TFH cells and the concentration of serum IL-21 in the AS patients were significantly higher than those in the healthy controls (P<0.0001, P=0.0027, P< 0.0001, P=0.0039, respectively). The frequency of FOXP3+CXCR5+CD4+TFR cells and the ratio of FOXP3+CXCR5+CD4+TFR/CXCR5+CD4+TFH cells still significantly rose in those patients after standard treatment (P=0.0006, P<0.0001), the concentration of serum IL-21 decreased after treatment (P=0.0049), accompanied by significantly minimized disease activities. Furthermore, the TFR cells were negatively correlated with serum immunoglobulinA in those patients before treatment (r=-0.582, P=0.0071), and the frequency of TFR cells was negatively correlated with that of TFH cells and the concentration of serum IL-21 after treatment (r=-0.550, P=0.046; r=-0.581, P=0.0371). TFR cells might participate in the pathogenesis of AS, and might be responsible for controlling the autoantibodies, the frequency and function of TFH cells to inhibit the development of AS.
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