期刊
THORAX
卷 71, 期 2, 页码 171-176出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2015-207697
关键词
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资金
- MRC [G1100196, MR/L002736/1] Funding Source: UKRI
- Medical Research Council [MR/L002736/1, G1100196] Funding Source: Medline
- Medical Research Council [G1100196, MR/L002736/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2014-09-005] Funding Source: researchfish
Introduction Postoperative pulmonary complications (PPC) such as atelectasis and pneumonia are common following lung resection. PPCs have a significant clinical impact on postoperative morbidity and mortality. We studied the long-term effects of PPCs and sought to identify independent risk factors. Methods A prospective observational study involved all patients following lung resection in a regional thoracic centre over 4 years. PPCs were assessed daily in hospital using the Melbourne group scale based on chest X-ray, white cell count, fever, purulent sputum, microbiology, oxygen saturations, physician diagnosis and intensive therapy unit (ITU)/high-dependency unit readmission. Follow-up included hospital length of stay (LOS), 30-day readmissions, and mortality. Results 86 of 670 patients (13%) who had undergone a lung resection developed a PPC. Those patients had a significantly longer hospital LOS in days (13, 95% CI 10.5-14.9 vs 6.3, 95% CI 5.9 to 6.7; p < 0.001) and higher rates of ITU admissions (28% vs 1.9%; p < 0.001) and 30-day hospital readmissions (20.7% vs 11.9%; p < 0.05). Significant independent risk factors for development of PPCs were COPD and smoking (p < 0.05), not age. Excluding early postoperative deaths, developing a PPC resulted in a significantly reduced overall survival in months (40, 95% CI 34 to 44 vs 46, 95% CI 44 to 47; p = 0.006). Those who developed a PPC had a higher rate of non-cancer-related deaths (11% vs 5%; p = 0.020). PPC is a significant independent risk factor for late deaths in non-small cell lung cancer patients (HR 2.0, 95% CI 1.9 to 3.2; p = 0.006). Conclusions Developing a PPC after thoracic surgery is common and is associated with a poorer long-term outcome.
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