期刊
THEORETICAL BIOLOGY AND MEDICAL MODELLING
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12976-016-0035-4
关键词
Hallmarks; Omics; Profiling; Therapy; Stem cell; Signaling networks; Tumor heterogeneity; Pharmacogenetics
资金
- CAPES-Fiocruz [001/2012]
- National Institute for Science and Technology on Innovation on Neglected Disease (INCT/IDN)
- National Institute for Science and Technology on Innovation on Neglected Diseases (CNPq) [573642/2008-7]
- Canadian Breast Cancer Foundation
- Allard Foundation
- Alberta Cancer Foundation
In this review, we report on breast cancer's molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast cancer therapies and challenges in order to progress towards its cure. Then, we show how the interaction of high-throughput technologies with in silico modeling has led to set up useful inferences for promising strategies of target-specific therapies with low secondary effect incidence for patients. Finally, we discuss the challenge of pharmacogenetics in the clinical practice of cancer therapy. All these issues are explored within the context of precision medicine.
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