期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 179, 期 2, 页码 137-145出版社
WILEY
DOI: 10.1111/cei.12467
关键词
angiotensin II; immunity; inflammation; rheumatoid arthritis
类别
资金
- National Natural Science Foundation of China [31200675, 81173075, 81330081]
- Natural Science Foundation of Anhui province [1208085QH158, 1408085QH173]
- Specialized Research Fund for the Doctoral Program of Higher Education [20123420110003]
- Grants for Scientific Research of BSKY from Anhui Medical University [XJ201215]
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that is characterized by increased cardiovascular morbidity and mortality, independent of the traditional risk factors for cardiovascular disease. Although classically known for its role in the regulation of circulatory homeostasis, angiotensin II (Ang II) is recognized to act as a powerful proinflammatory mediator. Some research has showed that Ang II plays important roles in autoimmune diseases, including RA, systemic lupus erythematosus and multiple sclerosis. Ang II blockers prove effective in reducing inflammation and autoimmunity in rheumatic diseases and their relative safety, together with their effects for reducing the cardiovascular disease risk, suggest that Ang II blockers may at least act as effective adjunctive therapy for disease control in patients with RA. The present review focuses systematically on the potential impact of Ang II and its receptors on inflammation and immunomodulation in patients with RA.
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