Acid-controlled switching of conformational preference of N,N-diarylamides bearing pyridine

Nuclear magnetic resonance (NMR) studies of acid-induced conformational switching (trans/cis isomerization) of N,N-diarylamides bearing a pyridine moiety indicated that the trans/cis conformational preference of these amides is dependent on the relative Pi-electron densities of the two N-aromatic parts, and can be controlled by protonation or deprotonation of pyridine. (C) 2016 Elsevier Ltd. All rights reserved.