期刊
TETRAHEDRON LETTERS
卷 57, 期 19, 页码 2121-2124出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.04.011
关键词
Copper; Quinoline; Regioselectivity; Radical reactions; C-H activation
资金
- National High-tech R&D Program of China [2013AA092903]
- National Natural Science Foundation of China [21502240]
- Guangdong Natural Science Foundation [S2013040012409, 2015A030313130]
Copper-catalyzed C-H sulfonylation of 8-aminoquinoline scaffolds in the unusual C5 position was developed. The protocol using inexpensive Cul as the catalyst and commercially available aryl sulfonyl chlorides as the sulfonylation reagents, shows broad substrate scope, producing moderate to good yield of sulfone. The developed method was conveniently applied to synthesize a potential fluorinated PET radioligand of 5-HT6 serotoninergic receptor. Moreover, mechanistic studies revealed that the reactions underwent a radical process. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据