Synthesis of β-prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles

A novel two-step synthesis of multisubstituted beta-prolinols has been developed, featuring a [3+2] cycloaddition of azomethine ylides and a programmed reduction triggered by the combination of borane and lithium aluminum hydride (LAH). beta-Prolinols are shown to be valuable building blocks for polyheterocycles. (C) 2016 Elsevier Ltd. All rights reserved.