期刊
TETRAHEDRON LETTERS
卷 57, 期 26, 页码 2901-2904出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.05.072
关键词
CPZEN-45; Catalytic asymmetric aldol reaction; Anti-XDR-TB agent
资金
- Grants-in-Aid for Scientific Research [26460168] Funding Source: KAKEN
A catalytic asymmetric total synthesis of CPZEN-45 (1), anti-XDR-TB agent, was accomplished using a direct aldol reaction of a glycine Schiff base (3) and uridine-derived aldehyde (4) catalyzed by Zn(II)-(R,R)-linked-BINOL complex to give the desired stereoisomer selectively. The diazepinone ring system, another key structural element, was successfully constructed by vinyl halide-amide coupling promoted by Cu(I) salt. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据