Palladium-catalyzed coupling reactions of 4-coumarinyl triflates with indoles leading to 4-indolyl coumarins

A convenient and efficient approach for the synthesis of 4-indolyl coumarins and 4-indolyl quinolinones was developed via palladium-catalyzed coupling reactions between 4-coumarinyl triflates/4-trifluoromethanesulfonyloxyquinolinones and indoles. Biological evaluation revealed that some of the obtained products exhibited in vitro antiproliferative activities on human-derived prostate, stomach, lung, breast cancer cell lines. (C) 2016 Elsevier Ltd. All rights reserved.