期刊
TETRAHEDRON LETTERS
卷 57, 期 38, 页码 4288-4292出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.08.024
关键词
Stylissa massa; Cycloheptapeptide; Stylissatins B-D; Structural elucidation; Cytotoxic effect
资金
- National Basic Research Program of China (973 Program) [2015CB755906]
- National Nature Science Foundation of China (NSFC) [41376127]
- NSFC-Shangdong Join Fund for Marine Science [U1406402]
The NMR and LC-MS guided chromatographic fractionation of the CH2Cl2 extract of the sponge Stylissa massa resulted in the isolation of three new cycloheptapeptides, namely stylissatins B-D (1-3), together with ten known cyclopeptides. The structures of stylissatins B-D were established by comprehensive analysis of 2D NMR (COSY, TOCSY, HMQC, HMBC, and ROESY) in association with the ESI-MS/MS fragmentation. The L-configuration of the amino acid residues was determined based on the Marfey's method. Stylissatin B (1) exhibited the inhibitory effects against a panel of human tumor cell lines including HCT-116, HepG2, BGC-823, NCI-H1650, A2780, and MCF7 with the IC50 values ranging from 2.4 to 9.8 M. (C) 2016 Elsevier Ltd. All rights reserved.
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