Recent advances on the synthesis of acylindoles

Acylindoles are valuable chemicals widely found in natural products, pharmaceuticals, and biologically active compounds. They are also important synthetic building blocks for chemical transformation. Recent advances of acylindoles synthesis via acylation of indoles with diverse carbonyl sources (N-allcylamines, aldehydes, alpha-oxocarboxylic acids, nitriles, olefins, CO, fluorinated acetic acids (salts), and dike tones) are highly desirable methods. Moreover, intramolecular cyclization of aminoalkynes and enaminones also provided highly efficient and atom-economical alternatives to the traditional methods. Herein, we summarize recent advances on the synthesis of acylindoles. (C) 2016 Elsevier Ltd. All rights reserved.