α-Alltylation of tertiary amines by C(sp3)-C(sp3) cross-coupling under redox neutral photocatalysis

Direct cc-alkylation of N-phenyl-tetrahydroisoquinoline with alkyl selenides of desired alkyl chain length and functionality is reported by photoredox catalysis. Construction of hexahydro pyrrolo- and pyrido-isoquinoline scaffolds along with indolines and tetrahydroquinolines is also described by intramolecular C(sp(3))-C(sp(3)) cross-couplings. (C) 2016 Elsevier Ltd. All rights reserved.