Tertiary amino thiourea-catalyzed asymmetric cross aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones

An enantioselective aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones catalyzed by tertiary amino thiourea has been established. Under mild conditions, the corresponding beta-trifluoromethyl-beta-hydroxy ketone products were obtained with up to 89% ee. (C) 2016 Elsevier Ltd. All rights reserved.