β-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123

Five new metabolites including four beta-resorcylic macrolides 1-4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound I displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 mu g/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS -1 832/13 pancreatic beta-cells by an EC50 value of 6.09 mu M and was noncytotoxic to Vero cells. (C) 2016 Elsevier Ltd. All rights reserved.