期刊
TETRAHEDRON
卷 72, 期 41, 页码 6421-6427出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.08.048
关键词
beta-Resorcylic macrolide; Octahydronaphthalene derivative; Antifungal activity; Cytotoxic activity; Protection of pancreatic beta-cells
资金
- NSTDA Chair Professor grant of the Crown Property Bureau Foundation
- National Science and Technology Development Agency
- Thailand Research Fund [DBG5980001]
- NSFC-TRF [81561148011]
- Faculty of Science, Prince of Songkla University
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Graduate School, Prince of Songkla University
- Department of Chemistry, Faculty of Science, Prince of Songkla University
Five new metabolites including four beta-resorcylic macrolides 1-4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound I displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 mu g/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS -1 832/13 pancreatic beta-cells by an EC50 value of 6.09 mu M and was noncytotoxic to Vero cells. (C) 2016 Elsevier Ltd. All rights reserved.
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