In(OTf)3/acid co-catalyzed hydration of 1-haloalkynes to α-halomethyl ketones

A novel and efficient In(OTT)(3) and HOAc cooperatively catalyzed hydration of 1-haloalkynes is described. This method provides ready access to alpha-chloromethyl ketones, alpha-bromomethyl ketones and alpha-iodomethyl ketones in moderate to high yields from simple, inexpensive starting materials. Abroad substrate scope is achieved, and the reaction is compatible with various functional groups, including alkoxy, trifluoromethyl, halide, hydroxyl, cyclohexyl, and heterocyclic groups. (C) 2016 Published by Elsevier Ltd.