期刊
TETRAHEDRON
卷 72, 期 21, 页码 2700-2706出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.12.002
关键词
Nucleophilic catalysis; Diastereoselectivity; Imines; Xiao-Phos; Chiral beta-aminophosphine
资金
- National Natural Science Foundation of China [21372084, 21425205]
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
Starting from commercially available aldehyde and chiral tert-butanesulfinamide, a series of chiral sulfinamide phosphines (Xiao-Phos) were synthesized via a two-step condensation-nucleophilic addition procedure. In most cases, nucleophilic addition of the N-tert-butanesulfinyl imine with diphenyl methyl phosphonic lithium showed high diastereoselectivity (d.r>20:1) with BF3 as additives. Following removal of the chiral auxilliary, an important class of ligands i.e chiral beta-aminophosphines and its derivatives were obtained in high yields using this approach. (C) 2015 Published by Elsevier Ltd.
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