期刊
TETRAHEDRON
卷 72, 期 37, 页码 5679-5683出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.07.080
关键词
Pyridone alkaloids; Endophytic fungus; Mangrove plant; Campylocarpon sp.; Cytotoxicity
资金
- National Natural Science Foundation of China [21372208]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
Two pairs of epimers, campyridones A and B (1 and 2) and campyridones C and D (3 and 4), were isolated from the mangrove endophytic fungus Campylocarpon sp. HDN13-307, as well as the biogenetically related known ilicicolin H (5). Their structures including absolute configurations were elucidated on the basis of the spectroscopic analysis and ECD calculations. The new compounds 1-4 possess unprecedented ring systems featured by the appearance of an additional spiro-furanone (1/2) or gamma-pyrone (3/4) moieties (C ring), which represents a new family of 4-hydroxy-2-pyridone alkaloids. Compounds 4 and 5 were cytotoxic against Hela cell with IC50 values of 8.8 mu M and 4.7 mu M, respectively. A plausible biosynthetic pathway for 1-4 is also elucidated. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据