Dehydrogenative Allylic Aminations of But-3-enoic Acid Derivatives

Two complementary Pd-catalyzed protocols enabling the gamma-selective intermolecular allylic amination of but-3-enoic acid derivatives are reported. These transformations can be successfully achieved via either a direct Pd(II)-catalyzed protocol or by way of a one-pot Pd(II)/Pd(0)-catalyzed sequence, depending on the nature of the nitrogen nucleophile used.