期刊
SYNTHESIS-STUTTGART
卷 48, 期 15, 页码 2376-2384出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561433
关键词
fluorine; halogenation; olefination; Wittig reaction; halogens
资金
- National Institutes of Health [GM106260]
Sequential chlorination/fluorination of aromatic trifluoroacetylated ketones gives 1-aryl 2-chloro-2,4,4,4-tetrafluorobutan-1,3-dione hydrates that are used for the synthesis of ketones and alkenes exhibiting a terminal bromochlorofluoromethyl group. The hydrates undergo detrifluoroacetylative cleavage and subsequent bromination in the presence of a copper(II) bisoxazoline catalyst, K2CO3, and NBS at room temperature. The corresponding bromochlorofluoromethyl ketones can be applied in Wittig and Horner-Wadsworth-Emmons reactions and dibromoalkenylations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据