期刊
SYNTHESIS-STUTTGART
卷 49, 期 7, 页码 1664-1674出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588672
关键词
multicomponent reactions; racetams; pyrrolidones; medicinal chemistry; Ugi reaction
资金
- Innovative Medicines Initiative Joint Undertaking project CHEM21 [115360]
- European Union's Seventh Framework Programme (FP7)
- EFPIA companies
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, gamma-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol is simple, general, and allows one-pot access to a range of drugs and bioactive small mole-cules.
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