期刊
SYNLETT
卷 27, 期 11, 页码 1653-1658出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561594
关键词
selenium dibromide; anchimeric assistance; seleniranium cation; rearrangement; 2-bromomethyl-1; 3-thiaselenol; nucleophilic substitution; unsaturated selenenyl sulfides; 2; 3-dihydro-1; 4-thiaselenines
资金
- Russian Foundation for Basic Research [16-03-00591_a]
The regio- and stereoselective reaction of 2-bromomethyl-1,3-thiaselenole with sodium N,N-dialkyl dithiocarbamates is accomplished at room temperature for two minutes in MeCN to afford (Z)-2-{[(dialkylamino)carbothioyl]sulfanylselanyl}ethenyl vinyl sulfides in up to 98% yield. At a longer time (8 h), the reaction regioselectively gives 2,3-dihydro-1,4-thiaselenin-2-yl N,N-dialkylcarbamodithioates in high yields. The latter are formed by rearrangement of the former compounds. DFT calculations show that the reactions proceed via a seleniranium intermediate. The formation of the products is the result of nucleophilic attacks of dithiocarbamate anion either at the selenium atom or at the carbon-2 atom of the seleniranium cation. The reaction leading to sulfanylselanylethenyl vinyl sulfides represents the first example of nucleophilic attack at the selenium atom of seleniranium intermediate.
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