期刊
SYNLETT
卷 27, 期 11, 页码 1725-1727出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561851
关键词
flavonoids; hydroxyaurones; chalcones; divergent; total synthesis; natural products
资金
- Cambridge Commonwealth Trust
- European Research Council under the European Union [279337/DOS]
- AstraZeneca
- European Union (EU)
- Engineering and Physical Sciences Research Council (EPSRC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Medical Research Council (MRC)
- Wellcome Trust
- Engineering and Physical Sciences Research Council [EP/J016012/1, EP/K039520/1] Funding Source: researchfish
- EPSRC [EP/K039520/1, EP/J016012/1] Funding Source: UKRI
The concise and step-economical total syntheses of three hydroxyaurones and one polymethoxyflavone from readily available starting materials is described. A divergent synthetic strategy is employed, which centres on a common chalcone scaffold from which both the aurone and flavone frameworks can be accessed through the use of different oxidative cyclisation methods. These are the first reported total syntheses of these biologically interesting compounds.
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