期刊
SYNLETT
卷 27, 期 10, 页码 1486-1510出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561379
关键词
aziridines; azetidines; beta-lactams; fluorine; ring opening
This account describes the endeavors made by our group concerning the synthesis of aziridines and azetidin(on)es and their use as novel building blocks for the preparation of nitrogen-containing organofluorine compounds. The majority of contributions, covered in the first part, comprises the study of fluorinated small-ring substrates, focusing on both their synthesis and their synthetic applicability for further transformations. These investigations revealed a pronounced effect of fluorine on the overall reactivity of small-ring azaheterocycles, often resulting in a different behavior compared with that of their nonfluorinated counterparts. In the second part, contributions are covered dealing with the transformation of nonfluorinated small rings into fluorinated target molecules upon treatment with fluorinated reagents. 1 Introduction 2 Synthesis and Reactivity of Fluorine-Containing Aziridines and Azetidines 2.1 Aziridines 2.2 Azetidines 3 Synthesis of Fluorine-Containing Nitrogen Compounds Starting from Nonfluorinated Aziridines and Azetidines 3.1 Aziridines 3.2 Azetidines 4 Conclusion and Outlook
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