期刊
SWISS MEDICAL WEEKLY
卷 146, 期 -, 页码 -出版社
E M H SWISS MEDICAL PUBLISHERS LTD
DOI: 10.4414/smw.2016.14347
关键词
ESCRT; endosomal sorting; MVB biogenesis; membrane remodelling; signal transduction; nuclear envelope; neurodegeneration; viral infection; cancer
资金
- AIRC Investigator Grant [15954]
- Telethon Grant [GPP13225]
- Cariplo Foundation
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.
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