期刊
CLINICAL & EXPERIMENTAL METASTASIS
卷 33, 期 1, 页码 97-113出版社
SPRINGER
DOI: 10.1007/s10585-015-9755-9
关键词
Aldehyde dehydrogenase; Metastasis; Solid tumors; Cancer stem cell; Biomarker
类别
资金
- Canadian Breast Cancer Foundation (Ontario Region)
- Canadian Institutes of Health Research (CIHR)
- CIHR New Investigator Award
- Ontario Ministry of Research and Innovation
There is accumulating evidence indicating that aldehyde dehydrogenase (ALDH) activity selects for cancer cells with increased aggressiveness, capacity for sustained proliferation, and plasticity in primary tumors. However, emerging data also suggests an important mechanistic role for the ALDH family of isoenzymes in the metastatic activity of tumor cells. Recent studies indicate that ALDH correlates with either increased or decreased metastatic capacity in a cellular context-dependent manner. Importantly, it appears that different ALDH isoforms support increased metastatic capacity in different tumor types. This review assesses the potential of ALDH as biological marker and mechanistic mediator of metastasis in solid tumors. In many malignancies, most notably in breast cancer, ALDH activity and expression appears to be a promising marker and potential therapeutic target for treating metastasis in the clinical setting.
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