期刊
CLINICA CHIMICA ACTA
卷 448, 期 -, 页码 228-231出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2015.06.022
关键词
Tumor marker; Increase; Kinetics; CEA; CA 15-3; Breast cancer; Recurrent disease; Metastatic disease; Early detection
Objective: We investigated the diagnostic capacity of CEA and CA 15-3 kinetics for the early detection of metastatic disease in comparison to fixed cut off values. Methods: In a retrospective analysis, a total of 743 patients with early breast cancer and available baseline values of CEA and CA 15-3 were included. A reproducible increase of 100% of single or combined markers was considered as a strong indicator of metastatic disease. Results: 187 patients developed metastatic disease and 556 remained disease-free. On the basis of tumor marker kinetics, we reached a specificity of >98% for both biomarkers and a sensitivity of 40.6% for CEA alone, 55.6% for CA 15-3 alone and 66.3% for the combination of both markers. Using fixed cut-off values (CEA: 4 ng/mL, CA 15-3: 30 U/mL) we ended up with a specificity of 86.3% and a sensitivity of 70.6% for the combination of CEA and CA 15-3. Using higher cut-off values (CEA: 6 ng/mL, CA 15-3: 60 U/mL) we reached a specificity of 96.9% and a sensitivity of 49.7% for the combination. Conclusion: We conclude that the interpretation of these markers in follow-up using individual baseline values and kinetics leads to a significant superior profile of specificity and sensitivity. (C) 2015 Elsevier B.V. All rights reserved.
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